SCI
26May
RegenerativeMetaplasticClonesinCOPDLungDriveInflammationandFibrosis
RaoWei,WangShan,DulebaMarcinetal.RegenerativeMetaplasticClonesinCOPDLungDriveInflammationandFibrosis.[J].Cell,,:-.e18.
Chronicobstructivepulmonarydisease(COPD)isaprogressiveconditionofchronicbronchitis,smallairwayobstruction,andemphysemathatrepresentsaleadingcauseofdeathworldwide.Whileinflammation,fibrosis,mucushypersecretion,andmetaplasticepitheliallesionsarehallmarksofthisdisease,theiroriginsanddependentrelationshipsremainunclear.Hereweapplysingle-cellcloningtechnologiestolungtissueofpatientswithandwithoutCOPD.Unlikecontrollungs,whichweredominatedbynormaldistalairwayprogenitorcells,COPDlungswereinundatedbythreevariantprogenitorsepigenetically
